PermaNet® 3.0 - Insecticide Resistance
Definition
'The selection of a heritable characteristic in an insect population that results in the repeated failure
of an insecticide product to provide the intended level of control when used as recommended.'
- Insecticide Resistance Action Committee (IRAC)
The various types
Resistance in mosquitoes can be due to one or a combination of the following mechanisms:
- Metabolic resistance (e.g. P450's/ esterases)
- Altered target-site resistance (e.g. kdr)
- Behavioral resistance
- Reduced penetration
Resistance development
- Natural selection allows pre-adapted insects with resistance genes to survive and pass on the
- resistance trait to offspring.
- As more product is applied, the resistant population keeps increasing while the susceptible individuals are eliminated by the insecticide.
- The product is eventually no longer effective.
- Speed of resistance development depends on many factors such as reproduction time, frequency of application of the insecticide and the proportion of susceptible insects.
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Top FAQ for PermaNet® 3.0
- What is PermaNet® 3.0, and how is it different from other bed nets?
- Why does PermaNet® 3.0 have an increased efficacy with pyrethroid-resistant malaria vectors?
- What does the rise of resistance mean for all of the bed nets currently in use around the world?
- How does PermaNet® 3.0 perform with different types and combinations of resistance mechanism?
- Why is resistance an important public health issue?
PermaNet® 3.0 Downloads
PermaNet® 3.0 Brochure (Portuguese)The Science Behind Malaria Prevention
"Before we used to get sick all the time": perceptions of malaria and use of long-lasting insecticide-treated bed nets (LLINs) in a rural Kenyan community